| Product name | PE-Cy7 anti-human IL-17A | | Catalog no | FHNILA | | Size | 25 tests | | Concentration |
| | Storage Buffer | Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA | | Storage Condition | Store at 4°C.DO NOT FREEZE. LIGHT SENSITIVE MATERIAL. | | Quality(Vol.) per. Test | 5 μl/test |
| Conjugate | PE-Cy7 | | Tested application | FC | | Clonality | Monoclonal | | Isotype | Mouse IgG1, κ | | Clone | 4ALB168 | | Host | Mouse | | Reactivity | Human | | Description | IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively. |
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