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工作日8:30-17:30

海星生物:文献报导|海星生物高分文献盘点

 二维码 5
发表时间:2024-05-28 14:13作者:诺扬生物来源:海星生物
海星生物致力于为广大药物研发、疫苗研发企业、医院、高校等科研机构工作者提供常用实验细胞系、肿瘤细胞等细胞产品。每年为行业成功构建上千例基因编辑细胞模型,包括基因敲除、基因突变和基因敲入、稳转和干扰细胞株,协助客户发表大量的高分文章。

公司发展愿景:“为科研加速,为工业赋能!”打造全球齐全的基因编辑细胞库和基因编辑技术平台。

发表引用文献达500+,产品引用发表期刊包括Nature Nanotechnology、Molecular Cancer、Immunity 等国际顶刊。


高分文献盘点

细胞系产品

1. HyCyte®细胞产品(U-2OS cell):影响因子为16

Gao Y, Zhu Y, Wang H, et al. Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination[J]. Molecular Cell, 2022, 82(7): 1313-1328. e8.

2. HyCyte®细胞产品(L929,NIH3T3):影响因子为11.2

Teng J, Zhao W, Zhang S, et al. Injectable nanoparticle-crosslinked xyloglucan/ε-poly-l-lysine composite hydrogel with hemostatic, antimicrobial, and angiogenic properties for infected wound healing[J]. Carbohydrate Polymers, 2024: 122102.

3. HyCyte®细胞产品(HUVEC):影响因子为9.8

Gao R, Jiang Z, Wu X, et al. Metabolic regulation of tumor cells exposed to different oxygenated polycyclic aromatic hydrocarbons[J]. Science of The Total Environment, 2024, 907: 167833.

4. HyCyte®双抗(青霉素/链霉素GUSA-R002):影响因子9

Zhou M, He J, Li Y, et al. N6-methyladenosine modification of REG1α facilitates colorectal cancer progression via β-catenin/MYC/LDHA axis mediated glycolytic reprogramming[J]. Cell Death & Disease, 2023, 14(8): 557.

5. HyCyte®HEK-293T细胞株:影响因子9

Zhang H, Zhao Y, Wang J, et al. FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division[J]. Cell Death & Disease, 2023, 14(6): 368.

6. HyCyte®HT22细胞株:影响因子8.8

Liu N, Cui X, Yan W, et al. Baicalein: a potential GLP-1R agonist improves cognitive disorder of diabetes through mitophagy enhancement[J]. Journal of Pharmaceutical Analysis, 2024: 100968.

7. HyCyte®U-2 OS细胞株:影响因子8.8

Wang W, Yang N, Wang L, et al. The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development[J]. Cell Reports, 2024, 43(3).

8. HyCyte®细胞试剂产品:影响因子8.8

Lu J, Wang R, Feng X, et al. Composite starch films as green adsorbents for removing benzo [a] pyrene from smoked sausages[J]. Food Chemistry, 2024, 441: 138297.

9. HyCyte®NK-92MI细胞株:影响因子8.4

Liu X, Wang Y, Ye B, et al. Catalyst-free thiazolidine formation chemistry enables the facile construction of peptide/protein–cell conjugates (PCCs) at physiological pH[J]. Chemical Science, 2023, 14(26): 7334-7345.

10. HyCyte®A549细胞株:影响因子8.4

Wang L L, Xu Q, Xie Y Z, et al. A triple-targeting fluorescent probe reveals the glutathione and viscosity crosstalk in mitochondria, endoplasmic reticulum, and nucleoli in cells during ferroptosis[J]. Sensors and Actuators B: Chemical, 2024, 399: 134872.

11. HyCyte®THP-1细胞株:影响因子8.2

Jiang F, Wu G, Yang H, et al. Diethylaminoethyl-dextran and monocyte cell membrane coated 1, 8-cineole delivery system for intracellular delivery and synergistic treatment of atherosclerosis[J]. International Journal of Biological Macromolecules, 2023, 253: 127365.

12. HyCyte®RAW 264.7细胞株:影响因子8.2

Li F, Liu T, Liu X, et al. Ganoderma lucidum polysaccharide hydrogel accelerates diabetic wound healing by regulating macrophage polarization[J]. International Journal of Biological Macromolecules, 2024, 260: 129682.

13. HyCyte®细胞系产品:影响因子8

Qi G, Shi G, Wang S, et al. A Novel pH-Responsive Iron Oxide Core-Shell Magnetic Mesoporous Silica Nanoparticle (M-MSN) System Encapsulating Doxorubicin (DOX) and Glucose Oxidase (Gox) for Pancreatic Cancer Treatment[J]. International Journal of Nanomedicine, 2023: 7133-7147.

14. HyCyte®细胞株产品(HEK-293T,Jurkat):影响因子8

Yu Z, Wu X, Zhu J, et al. BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma[J]. Cellular and Molecular Life Sciences, 2024, 81(1): 82.

15. 细胞株( THP-1,HCT116,Sw620,RAW264.7):影响因子7.9

Che N, Li M, Liu X, et al. Macelignan prevents colorectal cancer metastasis by inhibiting M2 macrophage polarization[J]. Phytomedicine, 2024, 122: 155144.

16. HyCyte®AML12细胞与细胞完全培养基:影响因子7.3

Gao J, Wang A, Bu X, et al. Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice[J]. Frontiers in Immunology, 2023, 14: 1169869.

17. HyCyte®NK-92细胞与细胞完全培养基:影响因子7.3

Zuo P, Li Y, He C, et al. Anti-tumor efficacy of anti-GD2 CAR NK-92 cells in diffuse intrinsic pontine gliomas[J]. Frontiers in immunology, 2023, 14: 1145706.

18. HyCyte®Nthy-ori3–1细胞株:影响因子6.8

Zhang X, Zhang Y, Feng X, et al. The role of estrogen receptors (ERs)-Notch pathway in thyroid toxicity induced by Di-2-ethylhexyl phthalate (DEHP) exposure: Population data and in vitro studies[J]. Ecotoxicology and Environmental Safety, 2024, 269: 115727.

19. HyCyte®HEK293T细胞株:影响因子6

Li P, Xi Y, Zhang Y, et al. GLA Mutations Suppress Autophagy and Stimulate Lysosome Generation in Fabry Disease[J]. Cells, 2024, 13(5): 437.

20. HyCyte®细胞株产品(5637,THP-1):影响因子5.8

Qi D, Lu Y, Qu H, et al. Independent prognostic value of CLDN6 in bladder cancer based on M2 macrophages related signature[J]. Iscience, 2024.

21. HyCyte®4T1细胞株:影响因子5.8

Zhao H Y, Li K H, Wang D D, et al. A mitochondria-targeting dihydroartemisinin derivative as a reactive oxygen species-based immunogenic cell death inducer[J]. Iscience, 2024, 27(1).

22. HyCyte®HK-2细胞株:影响因子5.8

Feng W, Zhu N, Xia Y, et al. Melanin-like nanoparticles alleviate ischemia-reperfusion injury in the kidney by scavenging reactive oxygen species and suppressing ferroptosis[J]. iScience, 2024.

23. HyCyte®细胞株产品(HaCaT,A-375,A-875,SK-MEL-1):影响因子5.7

Zhao Y, Wei Y, Fan L, et al. Leveraging a disulfidptosis-related signature to predict the prognosis and immunotherapy effectiveness of cutaneous melanoma based on machine learning[J]. Molecular Medicine, 2023, 29(1): 145.

24. HyCyte®RAW264.7细胞株:影响因子5.6

He S, Yan J, Chen L, et al. Structure and in vitro antioxidant and immunomodulatory activity of a glucan from the leaves of Cyclocarya paliurus[J]. Journal of Functional Foods, 2024, 113: 106016.

25. HyCyte®HL-1细胞株:影响因子5.6

Zhao Z, Jiang S, Fan Q, et al. Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity by regulating organic acid metabolism in gut microbiota[J]. Frontiers in Pharmacology, 2023, 14: 1286210.

26. HyCyte®C2C12细胞株:影响因子5.6

Chen Z, Li J, Bai Y, et al. Unlocking the Transcriptional Control of NCAPG in Bovine Myoblasts: CREB1 and MYOD1 as Key Players[J]. International Journal of Molecular Sciences, 2024, 25(5): 2506.

27. HyCyte®NK-92 MI细胞株:影响因子5.2

Liu F, Sang Y, Zheng Y, et al. circRNF10 regulates tumorigenic properties and natural killer cell-mediated cytotoxicity against breast cancer through the miR-934/PTEN/PI3k-Akt Axis[J]. Cancers, 2022, 14(23): 5862.

28. HyCyte®RAW264.7细胞株:影响因子5.2

Chen J, Lv Y, Shang W, et al. Loaded delta-hemolysin shapes the properties of Staphylococcus aureus membrane vesicles[J]. Frontiers in Microbiology, 2023, 14: 1254367.

29. HyCyte®PC细胞株:影响因子5.2

Hu H, He B, He M, et al. A glycosylation-related signature predicts survival in pancreatic cancer[J]. Aging (Albany NY), 2023, 15(23): 13710.

30. HyCyte®BV2细胞株:影响因子5

Duan W L, Ma Y P, Wang X J, et al. N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis[J]. European Journal of Pharmacology, 2024: 176553.

31. HyCyte®细胞株产品(A549, U87MG):影响因子4.9

Zhang Y, Wang Y, Chen Y, et al. PET Imaging of Peptide Probe Al [18F] F-NOTA-PCP1 for Monitoring the Engagement of PD-L1 Antibodies in Tumors[J]. Molecular Pharmaceutics, 2024.

32. HyCyte®人B淋巴细胞(GM12878):影响因子4.8

Liu C, Zhao X, Wang Z, et al. LncRNA CHROMR/miR-27b-3p/MET axis promotes the proliferation, invasion and contributes to rituximab resistance in diffuse large B-cell lymphoma[J]. Journal of Biological Chemistry, 2024: 105762.

33. HyCyte®THP-1细胞株:影响因子4.7

Wang Y, Mao J, Wang Y, et al. Multifunctional Exosomes Derived from M2 Macrophages with Enhanced Odontogenesis, Neurogenesis and Angiogenesis for Regenerative Endodontic Therapy: An In Vitro and In Vivo Investigation[J]. Biomedicines, 2024, 12(2): 441.

34. HyCyte®RAW264.7细胞株:影响因子4.6

Yang Y, Tang X, Yao T, et al. Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway[J]. Scientific Reports, 2024, 14(1): 1447.

35. HyCyte®HK-2 细胞株:影响因子4.5

Peng L, Wang C, Yu S, et al. Dysregulated lipid metabolism is associated with kidney allograft fibrosis[J]. Lipids in Health and Disease, 2024, 23(1): 37.

36. HyCyte®HepG2细胞株:影响因子4.5

Guan H, Zhong M, Ma K, et al. The Comprehensive Role of High Mobility Group Box 1 (HMGB1) Protein in Different Tumors: A Pan-Cancer Analysis[J]. Journal of Inflammation Research, 2023: 617-637.

37. HyCyte®Nthy-ori 3-1细胞株:影响因子4.3

Li X, Qian H, Ye H, et al. DEHP induces apoptosis and autophagy of the thyroid via Rap1 signaling pathway: In vivo and in vitro study[J]. Food and Chemical Toxicology, 2024: 114609.

38. HyCyte®MLE-12细胞株:影响因子4

Li Y, Xu H L, Kang X W, et al. MiR-2113 overexpression attenuates sepsis-induced acute pulmonary dysfunction, inflammation and fibrosis by inhibition of HMGB1[J]. Heliyon, 2024, 10(2).

39. HyCyte® U251细胞株:影响因子4

Li J, Wei Y, Liu J, et al. Integrative analysis of metabolism subtypes and identification of prognostic metabolism-related genes for glioblastoma[J]. Bioscience Reports, 2024, 44(3): BSR20231400.

40. HyCyte®   HEK239细胞株:影响因子3.7

Duan Y, Yu C, Kuang W, et al. Mesenchymal stem cell exosomes inhibit nucleus pulposus cell apoptosis via the miR-125b-5p/TRAF6/NF-κB pathway axis: Exosomes attenuate disc degeneration through the miR-125b/TRAF6/NF-κB axis[J]. Acta Biochimica et Biophysica Sinica, 2023, 55(12): 1938.

41. HyCyte®   h9C2细胞株:影响因子3.7

Yan Z, Liu Y, Yang B, et al. Endoplasmic reticulum stress caused by traumatic injury promotes cardiomyocyte apoptosis through acetylation modification of GRP78: GRP78 acetylation modification and cardiomyocyte apoptosis[J]. Acta Biochimica et Biophysica Sinica, 2024, 56(1): 96.

42. HyCyte®Caco-2细胞株:影响因子3.7

Zhou Q, Rao F, Chen Z, et al. The cwp66 gene affects cell adhesion, stress tolerance, and antibiotic resistance in Clostridioides difficile[J]. Microbiology Spectrum, 2022, 10(2): e02704-21.

43. HyCyte®细胞株产品(SH-SY5Y,SK-N-AS):影响因子3.6

Mengzhen Z, Xinwei H, Zeheng T, et al. Integrated machine learning-driven disulfidptosis profiling: CYFIP1 and EMILIN1 as therapeutic nodes in neuroblastoma[J]. Journal of Cancer Research and Clinical Oncology, 2024, 150(3): 109.

44 HyCyte®人脐静脉内皮细胞HUVEC:影响因子3.6

Su J, Cheng J, Hu Y, et al. Transfer RNA-derived small RNAs and their potential roles in the therapeutic heterogeneity of sacubitril/valsartan in heart failure patients after acute myocardial infarction[J]. Frontiers in Cardiovascular Medicine, 2022, 9: 961700.

45. HyCyte®H9C2细胞株:影响因子3.3

Mu F, Zhao J, Zhao M, et al. Styrax (Liquidambar orientalis Mill.) promotes mitochondrial function and reduces cardiac damage following myocardial ischemic injury: the role of the AMPK-PGC1α signaling pathway[J]. Journal of Pharmacy and Pharmacology, 2023, 75(12): 1496-1508.

46. HyCyte®人肺微血管内皮细胞/血清/培养基:影响因子3.1

Chen X, Chen J, Liu S, et al. PECAM-1 mediates temsirolimus-induced increase in neutrophil transendothelial migration that leads to lung injury[J]. Biochemical and Biophysical Research Communications, 2023, 682: 180-186.

47. HyCyte®细胞A549 human LUAD:影响因子2.9

Li P, Ma G, Cui Z, et al. FOXM1 and CENPF are associated with a poor prognosis through promoting proliferation and migration in lung adenocarcinoma[J]. Oncology Letters, 2023, 26(6): 1-13.

48. HyCyte®Human medullary TC cell line细胞株:影响因子2.9

Chen Z, Zhong X, Tang W, et al. Intracellular FGF1 promotes invasion and migration in thyroid carcinoma via HMGA1 independent of FGF receptors[J]. Endocrine Connections, 2023, 1(aop).

49. HyCyte®THP-1细胞株与细胞完全培养基:影响因子2.7

Du Y, Liu X, Xiao C, et al. TIPE2 regulates periodontal inflammation by inhibiting NF-κB p65 phosphorylation[J]. Journal of Applied Oral Science, 2023, 31: e20230162.

50. HyCyte®SW480细胞株:影响因子2.1

Zhang H, Zhou J, Ye Y. Prediction and validation of circulating G-quadruplexes as a novel biomarker in colorectal cancer[J]. Journal of Gastrointestinal Oncology, 2024, 15(1): 286.

51. HyCyte®THP-1细胞株

Chen Y, Chen S, Liu Z, et al. Noncanonical NLRP3 Inflammasome Activation Elicits the Programmed Death of Red Blood Cells[J]. Available at SSRN 4626203.

52. HyCyte®细胞产品(C-33A, SiHa)

Wu T, Wang W, Li Z, et al. Discovery of New Sesquiterpenoids And Jasmonic Acid Derivative From Artemisia Stolonifera And Their Anti-Inflammation Activity[J]. Available at SSRN 4691606.

血清产品

1. HyCyte®预筛选胎牛血清:影响因子为37.3

Zheng Z, Zeng X, Zhu Y, et al. CircPPAP2B controls metastasis of clear cell renal cell carcinoma via HNRNPC-dependent alternative splicing and targeting the miR-182-5p/CYP1B1 axis[J]. Molecular Cancer, 2024, 23(1): 4.

2. HyCyte®预筛选胎牛血清FBP-C520:影响因子为18.9

Li X, Liang X, Fu W, et al. Reversing cancer immunoediting phases with a tumor-activated and optically reinforced immunoscaffold[J]. Bioactive Materials, 2024, 35: 228-241.

3. HyCyte®预筛选胎牛血清:影响因子为5.7

Liu P, Wang Y, Li X, et al. Enhanced lipid biosynthesis in oral squamous cell carcinoma cancerassociated fibroblasts contributes to tumor progression: Role of IL8/AKT/pACLY axis[J]. Cancer Science, 2024.

4. HyCyte®预筛选胎牛血清

Liu P, Wang Y, Li X, et al. Enhanced lipid biosynthesis in OSCC cancer associated fibroblasts contributes to tumor progression: role of IL8/AKT/p-ACLY axis[J]. 2023.

5.HyCyte®预筛选胎牛血清与培养基:影响因子3.4

Zhao X, Zheng Z, Chen C, et al. New clerodane diterpenoids from Callicarpa pseudorubella and their antitumor proliferative activity[J]. Fitoterapia, 2024, 174: 105878.

6. HyCyte®血清/培养基:影响因子3.1
Chen X, Chen J, Liu S, et al. PECAM-1 mediates temsirolimus-induced increase in neutrophil transendothelial migration that leads to lung injury[J]. Biochemical and Biophysical Research Communications, 2023, 682: 180-186.


干细胞产品

1. 大鼠骨髓间充质干细胞三系分化试剂盒:影响因子18.9

Sun J, Yang F, Wang L, et al. Delivery of coenzyme Q10 loaded micelle targets mitochondrial ROS and enhances efficiency of mesenchymal stem cell therapy in intervertebral disc degeneration[J]. Bioactive Materials, 2023, 23: 247-260.

2. SD大鼠脂肪间充质干细胞:影响因子18.9

Ning X, Liu N, Sun T, et al. Promotion of adipose stem cell transplantation using GelMA hydrogel reinforced by PLCL/ADM short nanofibers[J]. Biomedical Materials, 2023, 18(6): 065003.

3. SD大鼠脂肪间充质干细胞三系分化试剂盒:影响因子18.9

Wei X, Wang L, Duan C, et al. Cardiac patches made of brown adipose-derived stem cell sheets and conductive electrospun nanofibers restore infarcted heart for ischemic myocardial infarction[J]. Bioactive Materials, 2023, 27: 271-287.

4. HyCyte®干细胞细胞产品:影响因子为18.9

Ma C, Qi X, Wei Y F, et al. Amelioration of ligamentum flavum hypertrophy using umbilical cord mesenchymal stromal cell-derived extracellular vesicles[J]. Bioactive materials, 2023, 19: 139-154.

5. HyCyte®干细胞细胞成软骨分化培养基:影响因子为16.6

Yang Y, Zhao X, Wang S, et al. Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration[J]. Nature Communications, 2023, 14(1): 7771.

6. HyCyte®干细胞三系诱导分化产品:影响因子为12.4

Sun Y, Liu Q, Qin Y, et al. Exosomes derived from CD271+ CD56+ bone marrow mesenchymal stem cell subpopoulation identified by single-cell RNA sequencing promote axon regeneration after spinal cord injury[J]. Theranostics, 2024, 14(2): 510.

7. HyCyte®干细胞三系诱导分化产品:影响因子为10.8

Sun Y, Zhao J, Liu Q, et al. Intranasal delivery of small extracellular vesicles from specific subpopulation of mesenchymal stem cells mitigates traumatic spinal cord injury[J]. Journal of Controlled Release, 2024, 369: 335-350.

8. HyCyte®干细胞三系诱导分化产品:影响因子为10.2

Lv Q, Wang Y, Tian W, et al. Exosomal miR-146a-5p derived from human umbilical cord mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast injury and placental dysfunction by regulating the TRAF6/NF-κB axis[J]. Journal of Nanobiotechnology, 2023, 21(1): 419.

9. HyCyte®成骨诱导液产品:影响因子10.2

Chen Y, Wu Y, Guo L, et al. Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by regulating macrophage polarization via DDX3X/NLRP3 axis[J]. Journal of Nanobiotechnology, 2023, 21(1): 98.

10. HyCyte®小鼠骨髓间充质干细胞成骨诱导分化培养基:影响因子7.9

Yang J, Zhang M, Luo Y, et al. Protopine ameliorates OVA-induced asthma through modulatingTLR4/MyD88/NF-κB pathway and NLRP3 inflammasome-mediated pyroptosis[J]. Phytomedicine, 2024: 155410.

11. HyCyte®干细胞三系诱导分化产品:影响因子为7.6

Li Z, Liu L, Yang Y, et al. Metformin Ameliorates Senescence of Adipose-Derived Mesenchymal Stem Cells and Attenuates Osteoarthritis Progression via the AMPK-Dependent Autophagy Pathway[J]. Oxidative Medicine and Cellular Longevity, 2022, 2022.

12. HyCyte®人脂肪干细胞完全培养基:影响因子7.5

Luan X, Chen P, Li Y, et al. TNF-α/IL-1β-licensed hADSCs alleviate cholestatic liver injury and fibrosis in mice via COX-2/PGE2 pathway[J]. Stem Cell Research & Therapy, 2023, 14(1): 100.

13. HyCyte®人骨髓间充质干细胞/干细胞完全培养基:影响因子6

Peng H, Zhang Y, Ren Z, et al. Cartilaginous Metabolomics Reveals the Biochemical-Niche Fate Control of Bone Marrow-Derived Stem Cells[J]. Cells, 2022, 11(19): 2951.

14. HyCyte®人骨髓成脂诱导培养基:影响因子5.8

Yao S, Zhou Z, Wang L, et al. Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH[J]. Iscience, 2023, 26(7): 107201.

15. HyCyte®干细胞成软骨和成脂诱导试剂盒:影响因子为5.6

Zhou J, Sui M, Ji F, et al. Hsa_circ_0036872 has an important promotional effect in enhancing osteogenesis of dental pulp stem cells by regulating the miR-143-3p/IGF2 axis[J]. International Immunopharmacology, 2024, 130: 111744.

16. HyCyte®人脂肪间充质干细胞:影响因子5.4

Duan J, Li Z, Liu E, et al. BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis[J]. Journal of Ethnopharmacology, 2023: 116692.

17. HyCyte®人脐带人间充质干细胞:影响因子4.8

Pu Y, Li C, Qi X, et al. Extracellular vesicles from NMN preconditioned mesenchymal stem cells ameliorated myocardial infarction via miR-210-3p promoted angiogenesis[J]. Stem Cell Reviews and Reports, 2023, 19(4): 1051-1066.

18. HyCyte®C57BL/6小鼠骨髓间充质干细胞与完全培养基:影响因子4.6

Liu P, Xie X, Wu H, et al. Conditioned medium of mesenchymal stem cells pretreated with H2O2 promotes intestinal mucosal repair in acute experimental colitis[J]. Scientific Reports, 2022, 12(1): 20772.

19. HyCyte®人骨髓间充质干细胞:影响因子4.6

Feng Z, Su X, Wang T, et al. Identification of biomarkers that modulate osteogenic differentiation in mesenchymal stem cells related to inflammation and immunity: A bioinformatics-based comprehensive study[J]. Pharmaceuticals, 2022, 15(9): 1094.

20. HyCyte®成人骨髓间充质干细胞完全培养基:影响因子4.3

Shen F, Xiao H, Shi Q. Mesenchymal stem cells derived from the fibrotic tissue of atrophic nonunion or the bone marrow of iliac crest: A donor-matched comparison[J]. Regenerative Therapy, 2023, 24: 398-406.

21. HyCyte® 人牙髓干细胞成骨分化试剂盒:影响因子3.9

Ning J, Zhang L, Xie H, et al. Decoding the multifaceted signatures and transcriptomic characteristics of stem cells derived from apical papilla and dental pulp of human supernumerary teeth[J]. Cell Biology International, 2023, 47(12): 1976-1986.

22. HyCyte®干细胞三系诱导试剂盒:影响因子3.1

Xia Y, Zhang Y, Sun Y, et al. CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts[J]. Biochemical and Biophysical Research Communications, 2023, 683: 149116.

23. HyCyte®MC3T3-E1成骨诱导分化培养基:影响因子2.7

Xie D, Xu Y, Cai W, et al. Icariin promotes osteogenic differentiation by upregulating alpha-enolase expression[J]. Biochemistry and Biophysics Reports, 2023, 34: 101471.

24. HyCyte®干细胞完全培养基与三系诱导试剂盒:影响因子2.6

Liu H, Li K, Guo B, et al. Engineering an injectable gellan gum-based hydrogel with osteogenesis and angiogenesis for bone regeneration[J]. Tissue and Cell, 2024, 86: 102279.

25. HyCyte®成骨诱导液产品:影响因子2.6

Dai H, Zhang H, Qiu Z, et al. Periosteum-derived Skeletal Stem Cells Encapsulated in Platelet-rich Plasma Enhance the Repair of Bone Defect[J]. Tissue and Cell, 2023: 102144.

26. HyCyte®成脂诱导培养基:影响因子1.8

Wang Z H, Peng J H, Liu Y C, et al. CCNB1 may as a biomarker for the adipogenic differentiation of adipose-derived stem cells in the postoperative fat transplantation of breast cancer[J]. Gland Surgery, 2024, 13(1): 45.

27. HyCyte®成骨/成脂诱导分化培养基

Xu Y, Xun J, Li Z, et al. Identification and characterization of human skeletal stem cell-like cells derived from infrapatellar fat pad[J]. 2023.

28. HyCyte®大鼠骨髓间充质干细胞成骨诱导分化培养基

Wang X, Hao Y, Chen X, et al. Local exosomes and Hoxa11 status affect the healing fate during autogenous bone grafting at different sites[J]. 2023.

29. HyCyte®人脐带间充质干细胞成骨/成脂诱导分化培养基

Zhang H, Zhu Q, Ji Y, et al. hucMSCs treatment prevents pulmonary fibrosis by reducing circANKRD42-YAP1-mediated mechanical stiffness[J]. Aging (Albany NY), 2023, 15(12): 5514.

30. HyCyte®大鼠骨髓间充质干细胞成骨分化试剂盒

Yao Z, Huang W, Yang Y, et al. Investigation of the Osteogenic Effects of ICA and ICSII on Rat Bone Marrow Mesenchymal Stem Cells[J]. 2024.

31.HyCyte®成脂诱导培养基

Guan C, **ao H, Chen Y, et al. Primary cilium of Prrx1+ cells mediate bone-tendon interface development by regulating cell biology[J]. 2023.


基因编辑技术服务

1. Cas9X®基因敲除服务:影响因子为39.3

Ma B, Ju A, Zhang S, et al. Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease[J]. Signal Transduction and Targeted Therapy, 2023, 8(1): 229.

【ALB in HepG2 was knocked out by Haixing Biosciences using the CRISPR/Cas9 system】


2. Cas9X®基因编辑服务(突变菌的基因改造和筛选):影响因子为26.6

Wu W, Pu Y, Gao S, et al. Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy[J]. Nano-Micro Letters, 2022, 14(1): 1-21.


3. Cas9X®基因敲除服务:影响因子为16.6

Bu J, Zhang Y, Wu S, et al. KK-LC-1 as a therapeutic target to eliminate ALDH+ stem cells in triple negative breast cancer[J]. Nature Communications, 2023, 14(1): 2602.

4. Cas9X®载体:影响因子为15.1

Chen X, Hao Y, Liu Y, et al. NAT10/ac4C/FOXP1 promotes malignant progression and facilitates immunosuppression by reprogramming glycolytic metabolism in cervical cancer[J]. Advanced Science, 2023, 10(32): 2302705.

5. Cas9X®基因敲除服务:影响因子为14.9

Cao X, Zheng J, Zhang R, et al. Live-cell imaging of human apurinic/apyrimidinic endonuclease 1 in the nucleus and nucleolus using a chaperone@ DNA probe[J]. Nucleic Acids Research, 2024: gkae202.

6. AV腺病毒 lncRNA LITTIP:影响因子14.9

Li T, Wang H, Jiang Y, et al. LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling[J]. International Journal of Oral Science, 2023, 15(1): 33.


7. Cas9X®基因过表达服务:影响因子为14.5

Fan H, Jiang H, Yu Z, et al. Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma[J]. Acta Pharmaceutica Sinica B, 2024.

8. Cas9X®基因敲除服务:影响因子为12.8

Yang H H, Jiang H L, Tao J H, et al. Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury[J]. Experimental & Molecular Medicine, 2022, 54(11): 2077-2091.

9. Cas9X®基因敲除服务:影响因子为12.4

Liu B, Hua D, Shen L, et al. NPC1 is required for postnatal islet β cell differentiation by maintaining mitochondria turnover[J]. Theranostics, 2024, 14(5): 2058.

10. 腺病毒包装:影响因子为11.4

Liu L, Wang L, Liu L, et al. Acyltransferase zinc finger DHHC-type containing 2 aggravates gastric carcinoma growth by targeting Nrf2 signaling: A mechanism-based multicombination bionic nano-drug therapy[J]. Redox Biology, 2024, 70: 103051.

11. 慢病毒包装:影响因子为10.2

Chen W, Li Z, Yu N, et al. Bone-targeting exosome nanoparticles activate Keap1/Nrf2/GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells[J]. Journal of Nanobiotechnology, 2023, 21(1): 355.

12. 慢病毒过表达载体:影响因子为10.2

Peng W, Xie Y, Luo Z, et al. UTX deletion promotes M2 macrophage polarization by epigenetically regulating endothelial cell-macrophage crosstalk after spinal cord injury[J]. Journal of Nanobiotechnology, 2023, 21(1): 225.

13. shRNA质粒:影响因子为9.3

Li W, Ali T, Zheng C, et al. Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression[J]. Journal of neuroinflammation, 2021, 18: 1-19.

14. Cas9X®基因敲除服务:影响因子为9.2

Zhong S, Guo Q, Chen X, et al. The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer[J]. International Journal of Biological Sciences, 2024, 20(3): 916.

15. CRISPR干扰服务:影响因子为7.9

Liu X, Yan C, Chang C, et al. Ochratoxin A promotes chronic enteritis and early colorectal cancer progression by targeting Rinck signaling[J]. Phytomedicine, 2024, 122: 155095.

16. Cas9X®基因敲除服务(敲除质粒/过表达质粒):影响因子为7.2

Dai J, Zhang L, Zhang R, et al. Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency Is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis[J]. Cellular and Molecular Gastroenterology and Hepatology, 2024, 17(3): 399-421.

17. Cas9X®基因敲除服务:影响因子为5.8

Zhou T, Qian H, Zhang D, et al. PGRN inhibits CD8+ T cell recruitment and promotes breast cancer progression by up-regulating ICAM-1 on TAM[J]. Cancer Immunology, Immunotherapy, 2024, 73(5): 76.

18. Cas9X®基因敲除服务:影响因子为5.6

Xu B, Sui Q, Hu H, et al. SAMHD1 attenuates acute inflammation by maintaining mitochondrial function in macrophages via interaction with VDAC1[J]. International Journal of Molecular Sciences, 2023, 24(9): 7888.

19. Cas9X®基因敲除服务:影响因子为5.6

Zhong W J, Ma L, Yang F, et al. Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia[J]. Frontiers in Pharmacology, 2022, 13: 1027441.

20. 基因敲除试剂盒(CRISPR-Cas9x3.0):影响因子为5.1

Xiao P, Chen J, Zeng Q, et al. UNC5B Overexpression alleviates peripheral neuropathic pain by stimulating netrin-1-dependent autophagic flux in Schwann cells[J]. Molecular Neurobiology, 2022, 59(8): 5041-5055.

21. siRNA干扰:影响因子为4.7

Huo D, Liang W, Wang D, et al. Roflupram alleviates autophagy defects and reduces mutant hSOD1-induced motor neuron damage in cell and mouse models of amyotrophic lateral sclerosis[J]. Neuropharmacology, 2024, 247: 109812.

22. Cas9X®基因敲除服务:影响因子为4.7

Lu Y, Zhang M X, Pang W, et al. Transcription factor ZNF683 inhibits SIV/HIV replication through regulating IFNγ secretion of CD8+ T cells[J]. Viruses, 2022, 14(4): 719.

23. Cas9X®基因载体服务:影响因子为3.9

Kang J, Abudurufu M, Zhang S, et al. lncRNA VIM-AS1 acts as a prognostic biomarker and promotes apoptosis in lung adenocarcinoma[J]. Journal of Cancer, 2023, 14(8): 1417.

24. Cas9X®基因稳转服务:影响因子为3.4

Liang C, Zhou J, Wang Y, et al. Essential genes analysis reveals small ribosomal subunit protein eS28 may be a prognostic factor and potential vulnerability in osteosarcoma[J]. Journal of Bone Oncology, 2024, 44: 100517.


25. Cas9X®基因过表达服务:影响因子为2.7

Li C, Lin X, Su J. HSP90B1 regulates autophagy via PI3K/AKT/mTOR signaling, mediating HNSC biological behaviors[J]. PeerJ, 2024, 12: e17028.

26. 细胞STR鉴定服务:影响因子为2.7

Wang C, Liu P, Sun Y, et al. Prognostic biomarker SYK and its correlation with immune infiltrates in glioma[J]. Experimental and Therapeutic Medicine, 2023, 26(4): 1-11.

27. Cas9X®基因编辑服务:影响因子为11

Li W, Ali T, Zheng C, et al. Anti-depressive-like behaviors of APN KO mice involve Trkb/BDNF signaling related neuroinflammatory changes[J]. Molecular Psychiatry, 2022, 27(2): 1047-1058.


28. 稳定转染过表达

Wang D, Yang S, Zeng Y, et al. TET2 amplifies RIPK3/MLKL necroptosis signal by upregulation of PLK3 to promote UVB-induced skin photodamage[J]. 2023.

29. Cas9X®基因敲除服务

Zhou T, Qian H, Zhang D, et al. Tumor-Derived PGRN Inhibits Cd8+ T Cell Recruitment and Promotes the Progression of Breast Cancer by Up-Regulation of ICAM-1 on TAM[J]. Available at SSRN 4204772.


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